The Arizona AHEC Program operates through the University of Arizona Health Sciences (UAHS), home to the UA College of Medicine - Tucson, College of Medicine - Phoenix, College of Nursing, College of Pharmacy, and Mel and Enid Zuckerman College of Public Health. Arizona AHEC is responsible to the Senior Vice President of Health Sciences at the UA. Arizona AHEC serves the State of Arizona contractually though six regional centers.

Arizona AHEC receives funds from federal and state sources. The federal fiscal year is September 1 through August 31, and the state fiscal year is July 1 to June 30. The federal award is from the U.S. Department of Health and Human Services, Health Resources and Services Administration, Bureau of Health Professions Model AHEC grant award. This federal award requires the program's regional centers to receive 75 percent of the funds with the remaining 25 percent going as support for the state program. State funds are allocated to Arizona AHEC through the Arizona State Lottery (per ARS 5-572C).